Woman, 64, nearly died of ‘toxic SQUASH syndrome’ after drinking trendy calabash juice

To the bitter end! Woman, 64, nearly died of ‘toxic SQUASH syndrome’ after being poisoned by trendy calabash juice

  • An unnamed 64 year old woman nearly died of toxic squash syndrome
  • The disease occurs when a person consumes toxic levels of cucurbitacin
  • Cucurbitacin is a naturally occurring toxin in gourds like pumpkins and squash

An elderly woman suffered a severe drop in blood pressure and body temperature after being poisoned by trendy fruit juice.

The unnamed patient, 64, suffered sudden weakness, nausea and vomiting just minutes after drinking calabash juice. The trendy drink has risen in popularity in recent years for its purported ability to reduce stress.

The woman was admitted to a local ER diagnosed with ‘toxic squash syndrome’ – a rare but potentially deadly disease that occurs when a person consumes a dangerous amount of cucurbitacin, a naturally occurring toxin in calabash.

Her blood pressure rapidly dropped to a dangerously low level and she could have died if she did not quickly seek medical attention.

The report is revealed as physicians also warn against other popular wellness trends, like taping a person’s mouth shut while sleeping to enhance breathing.

An unnamed woman suffered ‘toxic squash poisoning’ after she drank calabash juice. She noted that the drink was more bitter than usual. Her symptoms came about fast and dropped her blood pressure to dangerously low levels. She would survive after five days in the hospital (file photo)

The story was reported as a case report in the Canadian Journal of Emergency Medicine.

While the woman regularly enjoyed the drink – she noted to doctors that this time it was even more bitter.

This is a sign that there were higher levels of the toxic chemicals – which are found in gourds like pumpkins, cucumbers and calabash.

The toxin interrupts the ability for the body’s cells to send signals to one another – disrupting normal bodily functions and causing potentially deadly complications.

What is toxic squash syndrome?

Toxic squash syndrome is a rare but potentially deadly disease.

It occurs when a person consumes dangerous levels of the toxin cucurbitacin, which is naturally found in gourds like pumpkins, cucumbers and watermelons.

Symptoms onset quickly, often within minutes of consumption.

The toxin is extremely bitter, an indicator that food or drink can be contaminated.

Symptoms include sudden weakness, nausea, vomiting, diarrhea and abdominal pain.

A person can also suffer severe heart and breathing problems.

If left untreated, it can be fatal, but doctors will often be able to help patients resolve their symptoms in a matter of days.

While cucurbitacin is toxic, its antitumor properties have given it some scientists hope it can be used in the future for cancer medication.

It also weakens cell defenses, making them more vulnerable to infections and other illnesses.

Centuries of plant domestication and food science have allowed humans to grow gourds with inconsequential levels of the toxin.

Improved farming practices by amateur farmers can lead to the plants growing with concentrations of cucurbitacin that are dangerous to humans.

However, improper farming techniques could lead to an overabundance of them in some plants.

It was a homemade drink that the woman had regularly purchased at a local store.

She was also already suffering from high blood pressure and an overactive thyroid – a gland in the neck that distributes hormones around the body.

The woman suffers symptoms immediately after consuming the drink, including diarrhea and abdominal pain.

Her blood pressure dropped to unhealthy levels, from 142/90 to 46/27 in a matter of minutes when doctors examined her.

A level below 90/60 is considered dangerous, putting a person at risk of a stroke or heart attack.

She was also taking 18 breaths per minute, slightly more than the safe threshold of 16 per minute for a resting person, which could be an indication of lung or heart failure.

Her body temperature also fell from around 100 to 96F, lower than what is safe for adults but not low enough to be considered hypothermia. The woman’s extremities were also cold and tender to touch.

Over the next five days, she continued to have her blood pressure drop to unhealthy levels before rebounding later.

She was treated with electrolytes, drugs for high blood pressure and injections that would help diffuse acid in her stomach. The woman’s condition was resolved after five days.

Cucurbitacin is a bitter toxic substance whose purpose is to protect the plant from animals and bugs that may try to eat it.

Its ability to disrupt normal cell functions could prove valuable in the medical field.

It has shown promise in medicine, with the toxin having antitumor and anti-inflammatory properties

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Non-alcoholic cocktails to give you holiday cheer without the buzz

The holiday season comes with plenty of festivities every year — many of which involve alcohol.

“I think during the holidays, there are so many parties and dinners and gatherings for friends and family so obviously alcohol is everywhere,” says Hilary Sheinbaum, author of “The Dry Challenge: How to Lose the Booze for Dry January, Sober October, and Any Other Alcohol-Free Month.”

For whatever reason you or your friends choose not to consume alcohol (and, really, whose business is it anyway?), it’s nice to have drink options other than soda at holiday get togethers.

So, if you’re not drinking, looking to cut back or just don’t feel like having alcohol there are plenty of cocktails that can satisfy the festive-cup-quota without the buzz.

USA TODAY has gathered a few fun, holiday-themed NA cocktails that you can add to your holiday spread.

How sober are these ‘sober’ drinks? And why are they so popular?

Forget ‘Dry January’:Alcohol-free beer, wine, cocktails are available year round and are gaining popularity

Holiday gone sour

Holiday gone sour

Sheinbaum has a few cocktails of her own up her sleeve this holiday season. One includes sparkling water sweetened with simple syrup, lime juice and rosemary that sounds oh-so-refreshing for holiday functions.

Ingredients:

  • 12 ounces of water or sparkling water
  • .5 ounces of simple syrup
  • 2 ounces of lime juice
  • Ice
  • Rosemary sprigs (for garnish)

Instructions:

  1. Pour simple syrup into water, stir.
  2. Pour lime juice into the simple syrup water mixture, stir.
  3. Pour contents into a rock glass over ice.
  4. Garnish with rosemary sprigs.
  5. Enjoy!

Makes: 1 NA cocktail.

Sangria sweaters

Sangria sweaters

This recipe is fruity and fun and makes a few drinks.

Ingredients:

  • 16 ounces of sparkling white grape juice
  • 16 ounces ginger beer
  • Ice
  • Choice of garnishes, including:
    • 1/4 pineapple, peeled, cut into wedges
    • 1/2 small orange, cut into wedges
    • 1 passionfruit, quartered
    • 1/2 cup fresh mint leaves
    • Pomegranate seeds
    • Strawberries, sliced
    • Red and White grapes
    • Apple slices

Instructions:

  1. Pour equal amounts of juice and ginger beer in a pitcher.
  2. Stir.
  3. Serve over ice in festive glassware (or in a wine glass).
  4. Top with your choice of garnishes.
  5. Steer back and enjoy!

Makes: 4 NA cocktails.

Lyre’s Apertif

Lyre's Apertif

Mixer brand Fever Tree shared this NA cocktail recipe with USA TODAY from its Fever-Tree Easy Mixing Recipe Book.

Ingredients:

  • 2 ounces of Lyre’s Apéritif Dry
  • 6.8 ounces Fever-Tree Mediterranean Tonic Water​
  • 3 lemon wedges
  • Thyme sprigs, for garnish​

​Instructions:

  1. Pour the Lyre’s Apéritif Dry into a highball glass filled with ice cubes.
  2. Squeeze over and then drop in the lemon wedges.
  3. Top off with the tonic water.
  4. Garnish with a thyme sprig.

Makes: 1 NA cocktail.

Hot Non-Ginger Toddy

Hot Non-Ginger Toddy

Fever Tree shared a hot cocktail to warm party-attendees featuring hot apple cider, honey and ginger beer.

Ingredients:

  • 4 ounces of hot apple cider
  • .5 ounces of honey
  • 1 ounce of freshly squeezed lemon juice
  • Top with Fever-Tree ginger beer (or ginger beer of your choice)
  • Garnish with dusted apple slices and cinnamon stick

Instructions:

  1. Combine Hot cider, lemon juice and honey syrup in the mug.
  2. Top with Fever-Tree Ginger Beer.
  3. Garnish with an apple fan & cinnamon stick.

Makes: 1 NA cocktail.

The Lyre & The Blood Orange

The Lyre & The Blood Orange

Fever-Tree shared another recipe for “The Lyre & The Blood Orange” crafted by Rhett Hornberger of La Cuevita in Los Angeles.

Ingredients:

  • 1.5 ounces of Lyre’s AM Whiskey
  • .75 ounces of lemon juice
  • .75 ounces Liquid Alchemist Blood Orange Syrup
  • Fever-Tree’s Blood Orange Ginger Beer

Instructions:

  1. Shake ingredients in a shaker.
  2. Pour over ice in a Collins glass.
  3. Top with Fever-Tree’s Blood Orange Ginger Beer.
  4. Garnish with a blood orange half wheel.

Makes: 1 NA cocktail.

Mulled Jukes 6

Mulled Jukes 6

Jukes Cordialities, which sells apple cider-vinegar based non-alcoholic beverages that are meant to taste similar to wine, provided a cocktail made with Jukes 6, to USA TODAY.

Jukes 6 has a blackcurrant and blackberry base combined with layers of other red fruits including strawberries, plums and raspberries. When mixed with hot water and orange, the drink is meant to be sipped like a mulled wine.

Ingredients:

  • .5 ounces of Jukes 6, approximately half the bottle
  • 8 ounces of hot water
  • 1 slice of fresh or dried orange, for garnish

Instructions:

  1. Pour half a bottle of Jukes 6 – The Dark Red – into your favorite mug.
  2. Top with hot water.
  3. Garnish with a slice of fresh or dried orange and enjoy!

Makes: 1 NA cocktail.

Check out these recipes to up your kitchen game:

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Where to go out for dessert in Charlotte, NC

Open Rice's Bubble Waffles are made from a sweet batter, then filled with toppings and your choice of ice cream.

Open Rice’s Bubble Waffles are made from a sweet batter, then filled with toppings and your choice of ice cream.

Picture this: It’s date night and you’ve gone out to dinner, but you don’t want the night to end. You’re not looking to hit up the Charlotte bar or brewery scene, either. The easy solution: It’s time to go out for dessert.

It’s sometimes trickier than it sounds. Sure, you can probably stop in at almost any big chain restaurant and order something that will taste just fine. But that’s not your style, is it?

We’ve curated a list of some of our favorite local and North Carolina-based chain restaurants with great desserts that are open late-ish. You can use this list of go-to date night dessert spots to impress your companion with creative options for ice cream, chocolate creations and bakery treats without spending a lot of time hunting down a second reservation.

Charlotte’s 10 best places to get dessert are:

Amelie’s French Bakery & Cafe

Location: 136 E 36th St, Charlotte, NC 28205

Location: 7715 Pineville-Matthews Rd #34b, Charlotte, NC 28226

Location: 157 E Main St, Rock Hill, SC 29730

Location: 4321 Park Rd, Charlotte, NC 28209

Menu

What to know: There’s wine and beer available to pair with your dessert, along with a variety of coffee and tea options. Hours vary by location, but the flagship NoDa spot is open until 10 pm on weeknights and midnight Saturdays and Sundays.

What to order: Amelie’s classic salted caramel brownie ($5.30) and a 16 ounce S’more Latte ($5.20).

ameliessaltedcaramelbrownie
Amelie’s salted caramel brownie. Wendy Yang

Crave

Location: 500 West 5th Street, Suite 120, Charlotte, NC 28202

Menu

What to know: You’ve got to be 21+ to enter this upscale dessert and drinks bar — and there’s other food, too. It’s open late nights (until midnight on weekdays and 1 am on Saturdays), and don’t come looking scruffy (no athletic wear, ball caps or excessively casual attire). Open until midnight Sundays and Tuesdays through Thursdays, and until 1 am Fridays and Saturdays.

What to order: The S’mores Platter, featuring Hershey’s milk chocolate, graham crackers, marshmallows and a mini fire pit ($16).

Happyhour_1.JPG.JPG
Crave Dessert Bar’s S’Mores Platter. ROBERT LAHSER [email protected]

Day and Night Cereal Bars

Location: 127 Brevard Court, Charlotte, NC 28202

Menu

What to know: Day and Night Cereal Bar offers pre-made cereal bowls and shakes but also encourages customers to get creative. (You might even learn something new about your date.) It’s open until 10 pm Mondays through Saturdays and 6 pm on Sundays.

What to order: A Mucha Lucha bowl, which is Cinnamon Toast Crunch and whipped cream, topped with churro cereal and buttery cinnamon roll sprinkles ($8, or $10 as a shake.)

Day and Night Exotic Cereal Bar
Day and Night Exotic Cereal Bar serves cereal bowls and cereal milkshakes. Provided

Insomnia Cookies

Location: 210 E. Trade Street, #B-224, Charlotte, NC, 28202

Location: 2116 Hawkins Street, Suite 103, Charlotte, NC, 28203

Location: 9211 N Tryon Street, Space 4, Charlotte, NC, 28262

Menu

What to know: Insomnia Cookies is built around the idea that you’re going to want a cookies-and-milk nightcap. It’s open at multiple locations until midnight Sundays through Wednesdays and 1 am Thursdays through Saturdays — and you can even get delivery.

What to order: Just go ahead and pick out a dozen, with various flavors ($22).

insomnia_deluxe-flavors. jpg
Insomnia Cookies. Insomnia Cookies

Krispy Kreme

Locations: Multiple locations

Menu

What to know: Of course, you’ll find Krispy Kreme’s classic donuts, but now you’ll also find ice cream and shakes, too. Hours vary by location, but the South End location that’s home to the Krispy Kreme Innovation Center is open everyday until 10 pm

What to order: A Cookies and Kreme shake ($4.99.)

Krispy Kreme Ice Cream Shake Duo. jpg
Krispy Kreme serves seven hand-spun shakes, including Cookies and Kreme and Birthday Batter. Krispy Kreme

Open Rice

Location: 9882 Rea Road Suite F, Charlotte, NC, 28277

Menu

What to know: There’s a hefty selection of boba drinks to satisfy your sweet tooth at Open Rice, a fast-casual Asian restaurant that focuses on Hong Kong-style Chinese food. It’s open until 9 pm on weeknights and 9:30 pm on Fridays and Saturdays.

What to order: The Bubble Waffles. Choose your toppings, drizzles and one scoop of ice cream, with choices including chocolate, vanilla, cookies and cream, and green tea (price varies, depending on toppings).

Open Rice Bubble Waffle. jpeg
Open Rice’s Bubble Waffles are made from a sweet batter, then filled with toppings and your choice of ice cream. Courtesy of Open Rice

Sip Co.

Location: 50 Branchview Drive NE, Concord, NC 28025

Location: 9055 Carolina Lily Ln, Charlotte, NC 28262

Menu

What to know: Sip Co., a drink and snack spot where you can customize your beverages, is open until 10 pm Monday through Saturday.

What to order: A pink sugar cookie ($2.75) to pair

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